THERMATIC automatic climate control provides a pleasant constant temperature in the E-Class Coupé in any kind of weather. Sensors record the interior and exterior temperatures and other data such as the intensity and direction of sunlight, and for each of the two temperature zones individually adjust the heating, cooling or fan as necessary. The system also includes air recirculation, a defrost outlet for the windscreen and a fine dust filter.

Additional comfort is provided by the optional THERMATIC luxury 3-zone automatic climate control (standard for the E 500). It has separate temperature controls for the driver, front passengers and rear area. In addition the fully automatic climate styles of DIFFUSE, MEDIUM and FOCUS are available for selection. THERMOTRONIC keeps the desired temperature continually constant and takes other exterior factors such as sunlight, air quality and humidity into account via its sensors.