THERMATIC automatic climate control provides a pleasant constant temperature in the E-Class Cabriolet with the roof up in virtually all kinds of weather. Sensors register the interior and exterior temperatures and other data such as the intensity and direction of sunlight, adjusting the heating, cooling and fan setting for each of the two temperature zones individually as required. The system also includes air recirculation, a defrost outlet for the windscreen and a fine dust filter.

Additional comfort is provided by the optional THERMATIC luxury 3-zone automatic climate control (standard for the E 500). It has separate temperature controls for the driver, front passengers and rear area. In addition the fully automatic climate styles of DIFFUSE, MEDIUM and FOCUS are available for selection. THERMOTRONIC keeps the desired temperature continually constant and takes other exterior factors such as sunlight, air quality and humidity into account via its sensors.